Alzheimer and Dementia - a worldwide problem

People suffering
from demetia (mio)
Europe USA China Japan World
Increment 50 % 141 % 350 % 108 % 181 %
Today 8.7 5.8 10 4.6 46.8
2050 13.1 15 45 9.6 131.5
People suffering from dementia – increment today to 2050

Let us consult scientific publications. There are plenty of scientific publications showing that oxidative stress is causing Dementia, Alzheimer:

1. Oxidative stress in vascular Dementia and Alzheimer’s disease

"Alzheimer’s disease and vascular dementia are the two most common types of dementia with the former being the most predominant. It is evident that oxidative stress, an environment where pro-oxidant species overwhelm antioxidant species, is involved in the pathogenesis of both forms of Dementia."

2. Role of oxidative stress in Alzheimer’s disease

"Alzheimer's disease (AD) is the most common cause of disability in individuals aged >65 years worldwide. AD is characterized by the abnormal deposition of amyloid β (Aβ) peptide, and intracellular accumulation of neurofibrillary tangles of hyperphosphorylated τ protein and dementia. The neurotoxic oligomer Aβpeptide, which is the neuropathological diagnostic criterion of the disease, together with τprotein, are mediators of the neurodegeneration that is among the main causative factors. However, these phenomena are mainly initiated and enhanced by oxidative stress, a process referring to an imbalance between antioxidants and oxidants in favour of oxidants. This imbalance can occur as a result of increased free radicals or a decrease in antioxidant defense."

3. Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

"Alzheimer’s disease (AD) is a devastating neurodegenerative disorder without a cure. Most AD cases are sporadic where age represents the greatest risk factor. Lack of understanding of the disease mechanism hinders the development of efficacious therapeutic approaches. The loss of synapses in the affected brain regions correlates best with cognitive impairment in AD patients and has been considered as the early mechanism that precedes neuronal loss. Oxidative stress has been recognized as a contributing factor in aging and in the progression of multiple neurodegenerative diseases including AD. Increased production of reactive oxygen species (ROS) associated with age- and disease-dependent loss of mitochondrial function, altered metal homeostasis, and reduced antioxidant defense directly affect synaptic activity and neurotransmission in neurons leading to cognitive dysfunction. In addition, molecular targets affected by ROS include nuclear and mitochondrial DNA, lipids, proteins, calcium homeostasis, mitochondrial dynamics and function, cellular architecture, receptor trafficking and endocytosis, and energy homeostasis."

4. Publication on Twendee-X

"Oxidative stress plays an important role in the pathology of MCI and early stage of AD. Twendee-X is a strong antioxidative supplement containing 8 antioxidants, showing a significant amelioration of cognitive decline, amyloid-β pathology, neuronal loss, oxidative stress, and neuroinflammation in the AD model mice with chronic cerebral hypoperfusion and ischemic stroke model mice."

In the present study, chronic cerebral hypoperfusion, which is commonly found in aged Alzheimer's disease, significantly exacerbated motor dysfunction of APP23 mice from 5 months and cognitive deficit from 8 months of age, as well as neuronal loss, extracellular amyloid-β plaque and intracellular oligomer formations, and amyloid angiopathy at 12 months. Severe upregulations of oxidative markers and inflammatory markers were found in the cerebral cortex, hippocampus, and thalamus at 12 months. Twendee X treatment (20 mg/kg/d, from 4.5 to 12 months) substantially rescued the cognitive deficit and reduced the above amyloid-β pathology and neuronal loss, alleviated neuroinflammation and oxidative stress.

Download the whole publication here: >>> Publication Twendee-X

Further links: >>> Stroke Journal

What is the message and why is a super-antioxidant a great scientific success?

Reduce the oxidative stress caused by ROS and you improve your chances a lot to avoid Dementia and Alzheimer. By your life-style you can contribute to your mental health and prevent your brain from going dark.


1. Journal Alzheimers

Dis. 2009;17(2):245-57. doi: 10.3233/JAD-2009-1041.

Oxidative stress in vascular dementia and Alzheimer’s disease: a common pathology. Bennett S1, Grant MM, Aldred S.


2. Biomed Rep.

2016 May; 4(5): 519–522. Published online 2016 Mar 15. doi: 10.3892/br.2016.630 | PMCID: PMC4840676 | PMID: 27123241 | Role of oxidative stress in Alzheimer’s disease


3. Journal of Alzheimer's Disease

J of Alzheimer's Dis. 2017; 57(4): 1105–1121. Published online 2017 Apr 19. Prepublished online 2017 Dec 3. doi: 10.3233/JAD-161088 PMCID: PMC5409043 PMID: 28059794 Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease Eric Tönniesa and Eugenia Trushinaa,b,*

4. Publication of Twendee-X

Journal of Alzheimer Diseases 2019